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- Title
Formulation and Evaluation of Sustained Release Matrix Tablets of Captopril.
- Authors
Singh, Nisha; Singh, Gurdeep; Jain, Neetesh K.
- Abstract
The present investigation of this study was to develop Captopril SR matrix tablets that provide complete drug release that starts in the stomach to rapidly alleviate the symptoms and continues in the intestine to maintain its effect. Drug-polymer compatibility studies by FTIR gave confirmation about their purity and showed no interaction between drug and selected polymers. Various formulations were developed by using release rate controlling and gel-forming polymers like HPMC K100, ethyl cellulose and sodium CMC by direct compression method. Cellulose derivatives have been widely used in the formulation of hydrophilic matrix tablet for sustained drug delivery. From among all the developed formulations, F7 formulation sustained the drug release for longer period of time as compared to other formulations. So, F7 was selected as the best formulation. The best formulation was found to be stable during stability studies for two months. Thus, best formulation satisfied physicochemical parameters and in vitro drug release profile requirements for a sustained drug delivery system.
- Subjects
CAPTOPRIL; DRUG delivery systems; ETHYLCELLULOSE; DRUG interactions; DRUG tablets
- Publication
International Journal of Pharmacy & Life Sciences, 2020, Vol 11, Issue 11, p7071
- ISSN
0976-7126
- Publication type
Article