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- Title
Synthesis of Indolostilbenes via FeCl<sub>3</sub>-promoted Oxidative Cyclisation and their Biological Effects on NG108-15 Cell Viability and H<sub>2</sub>O<sub>2</sub>-induced Cytotoxicity.
- Authors
Azmi, Mohamad Nurul; Sian, Tan Aik; Suhaimi, Munirah; Kamarudin, Muhamad Noor Alfarizal; Md Din, Mohd Fadzli; Nafiah, Mohd Azlan; Thomas, Noel F.; Kadir, Habsah Abdul; Awang, Khalijah
- Abstract
A convenient and simple radical cation cyclisation of 3,5-dimethoxystilbene was developed using the commercially available FeCl3 under mild condition. It enabled the construction of a new class of indolostilbenes (i.e., indole-stilbene hybrid). Various parameters were investigated to obtain better yields (more than 42%) compared with the previously reported. The synthesised indolostilbenes were characterised, and their mechanism of formation was discussed. The synthesised compounds were submitted for biological assay on NG108-15 cell viability and H2O2-induced cytotoxicity. The result showed that two indolostilbenes have promising protective activity against H2O2.
- Subjects
RING formation (Chemistry); CELL survival; CHEMICAL synthesis; BIOLOGICAL assay; RADICAL cations
- Publication
Journal of Physical Science, 2021, Vol 32, Issue 1, p69
- ISSN
1675-3402
- Publication type
Article
- DOI
10.21315/jps2021.32.1.6