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- Title
Triglyceride to HDL Cholesterol Ratio for the Identification of MASLD in Obesity: A Liver Biopsy-Based Case-Control Study.
- Authors
Martínez-Montoro, José Ignacio; Martínez-Sánchez, María Antonia; Balaguer-Román, Andrés; Fernández-Ruiz, Virginia Esperanza; Hernández-Barceló, José Emilio; Ferrer-Gómez, Mercedes; Frutos, María Dolores; Núñez-Sánchez, María Ángeles; Fernández-García, José Carlos; Ramos-Molina, Bruno
- Abstract
Associations between dyslipidemia and metabolic dysfunction-associated steatotic liver disease (MASLD) have been reported. Previous studies have shown that the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio may be a surrogate marker of MASLD, assessed by liver ultrasound. However, no studies have evaluated the utility of this ratio according to biopsy-proven MASLD and its stages. Therefore, our aim was to evaluate if the TG/HDL-C ratio allows for the identification of biopsy-proven MASLD in patients with obesity. We conducted a case-control study in 153 patients with obesity who underwent metabolic surgery and had a concomitant liver biopsy. Fifty-three patients were classified as no MASLD, 45 patients as metabolic dysfunction-associated steatotic liver—MASL, and 55 patients as metabolic dysfunction-associated steatohepatitis—MASH. A receiver operating characteristic (ROC) analysis was performed to assess the accuracy of the TG/HDL-C ratio to detect MASLD. We also compared the area under the curve (AUC) of the TG/HDL-C ratio, serum TG, and HDL-C. A higher TG/HDL-C ratio was observed among patients with MASLD, compared with patients without MASLD. No differences in the TG/HDL-C ratio were found between participants with MASL and MASH. The greatest AUC was observed for the TG/HDL-C ratio (AUC 0.747, p < 0.001) with a cut-off point of 3.7 for detecting MASLD (sensitivity = 70%; specificity = 74.5%). However, no statistically significant differences between the AUC of the TG/HDL-C ratio and TG or HDL-C were observed to detect MASLD. In conclusion, although an elevated TG/HDL-C ratio can be found in patients with MASLD, this marker did not improve the detection of MASLD in our study population, compared with either serum TG or HDL-C.
- Subjects
OBESITY complications; HDL cholesterol; METABOLIC disorders; NON-alcoholic fatty liver disease; BIOPSY; BARIATRIC surgery; HYPERLIPIDEMIA; RECEIVER operating characteristic curves; RESEARCH funding; DESCRIPTIVE statistics; CASE-control method; TRIGLYCERIDES; DATA analysis software; BIOMARKERS; DISEASE complications
- Publication
Nutrients, 2024, Vol 16, Issue 9, p1310
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu16091310