We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Fat-Soluble Vitamers: Parent-Child Concordance and Population Epidemiology in the Longitudinal Study of Australian Children.
- Authors
Arachchige, Githal Randunu Porawakara; Pook, Chris James; Jones, Beatrix; Coe, Margaret; Saffery, Richard; Wake, Melissa; Thorstensen, Eric Bruce; O'Sullivan, Justin Martin
- Abstract
Fat-soluble vitamers (FSV) are a class of diverse organic substances important in a wide range of biological processes, including immune function, vision, bone health, and coagulation. Profiling FSV in parents and children enables insights into gene-environment contributions to their circulating levels, but no studies have reported on the population epidemiology of FSV in these groups as of yet. In this study, we report distributions of FSV, their parent-child concordance and variation by key characteristics for 2490 children (aged 11–12 years) and adults (aged 28–71 years) in the Child Health CheckPoint of the Longitudinal Study of Australian Children. Ten A, D, E and K vitamers were quantified using a novel automated LC-MS/MS method. All three K vitamers (i.e., K1, MK-4, MK-7) and 1-α-25(OH)2D3 were below the instrument detection limit and were removed from the present analysis. We observed a strong vitamer-specific parent-child concordance for the six quantifiable A, D and E FSVs. FSV concentrations all varied by age, BMI, and sex. We provide the first cross-sectional population values for multiple FSV. Future studies could examine relative genetic vs. environmental determinants of FSV, how FSV values change longitudinally, and how they contribute to future health and disease.
- Subjects
AUSTRALIA; VITAMIN metabolism; VITAMINS; VITAMIN E; AGE distribution; GAS chromatography; VITAMIN D; SEX distribution; MASS spectrometry; VITAMIN A; BODY mass index; LONGITUDINAL method; EPIDEMIOLOGICAL research; VITAMIN K; CHILDREN; ADULTS
- Publication
Nutrients, 2022, Vol 14, Issue 23, p4990
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu14234990