We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Analysis of Serum Fatty Acids Profile in Kidney Transplant Recipients.
- Authors
Mika, Adriana; Halinski, Lukasz P; Sledzinski, Tomasz; Malgorzewicz, Sylwia; Woloszyk, Paulina; Dardzinska, Jolanta; Debska-Slizien, Alicja; Chmielewski, Michal; Morishita, Yoshiyuki
- Abstract
Patients with end-stage kidney disease, treated with renal transplantation, are at increased risk of cardio-vascular disease (CVD) and cardio-vascular mortality. They are also characterized by an atherogenic dyslipidemia. Alterations of the fatty acids (FA) profile contribute to increased cardio-vascular risk in the general population. In the current study we test the hypothesis that kidney transplantation is associated with ab-normalities in FA profile. FA profile was analysed by gas chromatography–mass spectrometry in 198 renal transplant recipients, and 48 control subjects. The most profound differences between renal transplant patients and controls were related to the content of branched chain FA, monounsaturated FA, and n-6 polyunsaturated FA, respectively. The FA profile significantly separated the patients from the controls in the principal component analysis (PCA). The abnormalities of FA profile showed a tendency for normalization in long-term kidney recipients, as compared to patients with recent transplants. The n-3 PUFA content demonstrated a strong inverse association with the presence of inflammation. Most profound alterations of the FA profile were observed in patients with impaired graft function (glomerular filtration rate < 45 mL/min). The study demonstrated significant disorders of the FA profile in kidney transplant recipients, that might contribute to cardio-vascular risk in this vulnerable patient population.
- Subjects
BLOOD serum analysis; UNSATURATED fatty acids; CARDIOVASCULAR diseases risk factors; INFLAMMATION; KIDNEY transplantation; DIABETES; GAS chromatography; MASS spectrometry; FACTOR analysis; OMEGA-3 fatty acids; FATTY acids; TRANSPLANTATION of organs, tissues, etc.
- Publication
Nutrients, 2021, Vol 13, Issue 3, p805
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu13030805