We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Short-Communication: Ingestion of a Nucleotide-Rich Mixed Meal Increases Serum Uric Acid Concentrations but Does Not Affect Postprandial Blood Glucose or Serum Insulin Responses in Young Adults.
- Authors
Coelho, Mariana O. C.; Monteyne, Alistair J.; Kamalanathan, Ishara D.; Najdanovic-Visak, Vesna; Finnigan, Tim J. A.; Stephens, Francis B.; Wall, Benjamin T.
- Abstract
Circulating uric acid concentrations have been linked to various metabolic diseases. Consumption of large boluses of nucleotides increases serum uric acid concentrations. We investigated the effect of a nucleotide-rich mixed meal on postprandial circulating uric acid, glucose, and insulin responses. Ten healthy adults participated in a randomised, controlled, double-blind, crossover trial in which they consumed a mixed-meal containing either nucleotide-depleted mycoprotein (L-NU) or high-nucleotide mycoprotein (H-NU) on two separate visits. Blood samples were collected in the postabsorptive state and throughout a 24 h postprandial period, and were used to determine circulating uric acid, glucose, and insulin concentrations. Mixed meal ingestion had divergent effects on serum uric acid concentrations across conditions (time x condition interaction; P < 0.001), with L-NU decreasing transiently (from 45 to 240 min postprandially) by ~7% (from 279 ± 16 to 257 ± 14 µmol·L−1) and H-NU resulting in a ~12% increase (from 284 ± 13 to 319 ± 12 µmol·L−1 after 210 min), remaining elevated for 12 h and returning to baseline concentrations after 24 h. There were no differences between conditions in blood glucose or serum insulin responses, nor in indices of insulin sensitivity. The ingestion of a nucleotide-rich mixed-meal increases serum uric acid concentrations for ~12 h, but does not influence postprandial blood glucose or serum insulin concentrations.
- Subjects
BLOOD collection; BLOOD sugar; CROSSOVER trials; INGESTION; INSULIN; NUCLEOTIDES; STATISTICAL sampling; URIC acid; RANDOMIZED controlled trials; BLIND experiment
- Publication
Nutrients, 2020, Vol 12, Issue 4, p1115
- ISSN
2072-6643
- Publication type
Article
- DOI
10.3390/nu12041115