We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Growth Hormone and Sex Steroid Administration in Healthy Aged Women and Men: A Randomized Controlled Trial.
- Authors
Blackman, Marc R.; Sorkin, John D.; Münzer, Thomas; Bellantoni, Michele F.; Busby-Whitehead, Jan; Stevens, Thomas E.; Jayme, Jocelyn; O'Connor, Kieran G.; Christmas, Colleen; Tobin, Jordan D.; Stewart, Kerry J.; Cottrell, Ernest; St. Clair, Carol; Pabst, Katharine M.; Harman, S. Mitchell
- Abstract
Context: Hormone administration to elderly individuals can increase lean body mass (LBM) and decrease fat, but interactive effects of growth hormone (GH) and sex steroids and their influence on strength and endurance are unknown. Objective: To evaluate the effects of recombinant human GH and/or sex steroids on body composition, strength, endurance, and adverse outcomes in aged persons. Design, Setting, and Participants: A 26-week randomized, double-blind, placebo-controlled parallel-group trial in healthy, ambulatory, community-dwelling US women (n = 57) and men (n = 74) aged 65 to 88 years recruited between June 1992 and July 1998. Interventions: Participants were randomized to receive GH (starting dose, 30 µg/kg, reduced to 20 µg/kg, subcutaneously 3 times/wk) + sex steroids (women: transdermal estradiol, 100 µg/d, plus oral medroxyprogesterone acetate, 10 mg/d, during the last 10 days of each 28-day cycle [HRT]; men: testosterone enanthate, biweekly intramuscular injections of 100 mg) (n = 35); GH + placebo sex steroid (n = 30); sex steroid + placebo GH (n = 35); or placebo GH + placebo sex steroid (n = 31) in a 2 × 2 factorial design. Main Outcome Measures: Lean body mass, fat mass, muscle strength, maximum oxygen uptake (VO[sub 2]max) during treadmill test, and adverse effects. Results: In women, LBM increased by 0.4 kg with placebo, 1.2 kg with HRT (P = .09), 1.0 kg with GH (P = .001), and 2.1 kg with GH + HRT (P<.001). Fat mass decreased significantly in the GH and GH + HRT groups. In men, LBM increased by 0.1 kg with placebo, 1.4 kg with testosterone (P = .06), 3.1 kg with GH (P<.001), and 4.3 kg with GH + testosterone (P<.001). Fat mass decreased significantly with GH and GH + testosterone. Women's strength decreased in the placebo group and increased nonsignificantly with HRT (P = .09), GH (P = .29), and GH + HRT (P = .14). Men's strength also did not increase significantly except for a marginally significant increase of 13.5 kg...
- Subjects
HORMONE therapy; PREVENTIVE medicine; AGING endocrinology; PHYSIOLOGY
- Publication
JAMA: Journal of the American Medical Association, 2002, Vol 288, Issue 18, p2282
- ISSN
0098-7484
- Publication type
Article
- DOI
10.1001/jama.288.18.2282