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- Title
Zinc supplementation and growth in sickle cell disease.
- Authors
Prasad, Ananda S.; Cossack, Zafrallah T.; Prasad, A S; Cossack, Z T
- Abstract
With the use of flameless atomic absorption spectrophotometry, we have devised a technique for measuring zinc in neutrophils. Neutrophil zinc levels in patients with sickle cell anemia correlated significantly with height and weight, and with serum testosterone in men. Such correlations were not seen with zinc levels in plasma or erythrocytes. We also report the beneficial effects of zinc supplementation on longitudinal growth and body weight in 14- to 18-year-old patients with sickle cell anemia. Thus, the neutrophil zinc level is a reliable and sensitive indicator of zinc deficiency in these patients.
- Subjects
ZINC in the body; NEUTROPHILS; SICKLE cell anemia; THERAPEUTIC use of zinc; ERYTHROCYTES; BLOOD plasma; COMPARATIVE studies; GROWTH disorders; RESEARCH methodology; MEDICAL cooperation; RESEARCH; STATISTICAL sampling; ZINC; EVALUATION research; DISEASE complications
- Publication
Annals of Internal Medicine, 1984, Vol 100, Issue 3, p367
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-100-3-367