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- Title
IDENTIFICATION AND ANTIFUNGAL SUSCEPTIBILITIES CANDIDA SPECIES ISOLATED FROM NAIL INFECTION.
- Authors
Katiraee, Farzad; Ghaderi, Adel; Ghaderi, Shahla
- Abstract
Introduction and Objectives: Onychomycosis is a fungal persistent infection of the nail bed and plate by dermatophytes, yeasts or mould species. This study presents ethologic agents of Candida onychomycosis and the determination of in vitro susceptibility patterns of isolated Candida species in multiple private laboratories in Tehran. Materials and Methods: Nail samples were taken from 120 patients with suspected fingernails and toenail onychomycosis during 2011. The direct microscopy with KOH and culture examinations of the nail samples was performed to identify the etiologic agent. Candida species identified by conventional methods. To select antifungal agents, the in vitro susceptibility of the isolates was performed by disc diffusion method. Results: Samples from 35 patients (29.1%) were positive for Candida onychomycosis. Candida albicans (54.3%), C. glabrata (11. 4%), C. parapsilosis (11.4), C. tropicalis (8.6%), C. guilliermondii (5. 8%), C. famata (5.8%), and C. Kefyr (2.9%) were the most frequent species isolated. Females affected more frequently than male and in both sexes, the age group of 20- 40 years old were more affected. Fingernails were affected more frequently than toenails (P < 0. 05). The majority of isolates were susceptible to amphotericin B and nystatin (97.1%), itraconazole (88.6%), fluconazole (80%), and ketoconazole (82. 8%), clotrimazole (82.8%). Conclusion: The yeasts of genus Candida are one of the most important causal agents of onychomycosis and susceptibility testing of nail isolates of Candida species could be considered in the successful treatment in case of relapse or chronic disease.
- Subjects
TEHRAN (Iran); CANDIDA; NAIL diseases; ONYCHOMYCOSIS; DERMATOMYCOSES; PATHOLOGICAL laboratories; AGE groups
- Publication
Jundishapur Journal of Microbiology, 2013, p7
- ISSN
2008-3645
- Publication type
Article