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- Title
Progressive multifocal leukoencephalopathy in multiple myeloma.
- Authors
Hoeynck, Brian W.; Cohen, Adam D.; Stadtmauer, Edward A.; Susanibar‐Adaniya, Sandra P.; Vogl, Dan T.; Waxman, Adam J.; Bardsley, Mark; Le, Samantha; LaMaestra, Lexis; Garfall, Alfred L.
- Abstract
Progressive multifocal leukoencephalopathy (PML) is a rare and often fatal demyelinating disease of the central nervous system caused by reactivation of the JC virus in the context of immune suppression such as HIV, malignancy, and certain immunomodulatory medications. PML has been reported only rarely in multiple myeloma patients, and its presenting features and natural history in this population are not well known. We describe six cases of PML among multiple myeloma patients treated at our institution between 2013 and 2022, including two that developed on or shortly after treatment with recently developed BCMA‐directed immunotherapies.
- Subjects
PROGRESSIVE multifocal leukoencephalopathy; JOHN Cunningham virus; MULTIPLE myeloma; CENTRAL nervous system diseases
- Publication
European Journal of Haematology, 2023, Vol 110, Issue 3, p322
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/ejh.13909