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- Title
Comparison of transplant-specific prognostic scoring systems in haploidentical transplantation for myelodysplastic syndrome.
- Authors
Seung-Hwan Shin; Young-Woo Jeon; Jae-Ho Yoon; Seung-Ah Yahng; Sung-Eun Lee; Byung-Sik Cho; Ki-Seong Eom; Seok Lee; Hee-Je Kim; Chang-Ki Min; Seok-Goo Cho; Dong-Wook Kim; Jong-Wook Lee; Woo-Sung Min; Yoo-Jin Kim
- Abstract
Objectives: We intended to identify the predictive abilities of recently published transplant-specific prognostic scoring systems in patients with myelodysplastic syndrome (MDS) receiving haploidentical transplantation. Methods: The outcomes of 73 patients with MDS receiving haploidentical transplantation were analyzed, according to the MTPSS, the TRI, and the CIBMTR scoring systems. Results: The median age of patients at transplantation was 50 (range, 19-69) years. The IPSS-R cytogenetic risks of very good/good, intermediate, and poor/very poor were, respectively, observed in 35 (48.0%), 25 (34.2%), and 13 (17.8%) patients, including 4 (5.5%) with a monosomal karyotype. Pretransplant treatment failure and high (≥3) HCT-CI were observed in 30 (41.1%) and 35 (48.0%) patients, respectively. With survivor's median follow-up of 42.3 months, the overall survival rate at 4 years of all patients was 65.5% (95% CI, 52.4-75.9). The MTPSS (100%, 77.3%, 62.5%, and 42.0% at 4 years; P = .02) and the TRI (100%, 79.9%, 76.0%, and 17.1% at 4 years; P < .01) differentiate proportionally overall survival rates according to their 4 risk groups, whereas the CIBMTR scoring system did not (P = .17). Conclusions: Our results suggest the potential ability of the MPTSS and the TRI as prognostic tools for patients with MDS receiving haploidentical transplantation.
- Subjects
STEM cell transplantation; MYELODYSPLASTIC syndromes; TRICHLOROETHYLENE; CYTOGENETICS; KARYOTYPES
- Publication
European Journal of Haematology, 2018, Vol 101, Issue 2, p200
- ISSN
0902-4441
- Publication type
Article
- DOI
10.1111/ejh.13095