We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Resting-state functional MRI demonstrates brain network reorganization in neuromyelitis optica spectrum disorder (NMOSD).
- Authors
Bigaut, Kévin; Achard, Sophie; Hemmert, Céline; Baloglu, Seyyid; Kremer, Laurent; Collongues, Nicolas; De Sèze, Jérôme; Kremer, Stéphane
- Abstract
Background: The relation between brain functional connectivity of patients with neuromyelitis optica spectrum disorder (NMOSD) and the degree of disability remains unclear. Objective: Compare brain functional connectivity of patients with NMOSD to healthy subjects in resting-state functional MRI (rs-fMRI). Methods: We compared the rs-fMRI connectivity in 12 NMOSD patients with 20 healthy subjects matched for age and sex. Graph theory analysis was used to quantify the role of each node using a set of metrics: degree, global efficiency, clustering and modularity. To summarize the abnormal connectivity profile of brain regions in patients compared to healthy subjects, we defined a hub disruption index κ. Results: Concerning the global organization of networks in NMOSD, a small-world topology was preserved without significant modification concerning all average metrics. However, visual networks and the sensorimotor network showed decreased connectivity with high interindividual variability. The hub disruption index κ was correlated to the Expanded Disability Status Scale (EDSS). Conclusion: These results demonstrate a correlation between disability according to the EDSS and neuronal reorganization using the rs-fMRI graph methodology. The conservation of a normal global topological structure despite local modifications in functional connectivity seems to show brain plasticity in response to the disability.
- Subjects
NEUROMYELITIS optica; MAGNETIC resonance imaging of the brain; BRAIN function localization; NEURAL circuitry; GRAPH theory
- Publication
PLoS ONE, 2019, Vol 14, Issue 1, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0211465