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- Title
Tricyclic and Spirobicyclic Norsesquiterpenes from the Endophytic Fungus Pseudolagarobasidium acaciicola.
- Authors
Wibowo, Mario; Prachyawarakorn, Vilailak; Aree, Thammarat; Wiyakrutta, Suthep; Mahidol, Chulabhorn; Ruchirawat, Somsak; Kittakoop, Prasat
- Abstract
The new tricyclic and spirobicyclic norsesquiterpenes 1 and 2 and the new nor-chamigrane endoperoxide 3, together with the known sesquiterpenes steperoxide A ( 4), merulin B ( 5), and merulin C ( 6), were isolated from the endophytic fungus Pseudolagarobasidium acaciicola. The structures and absolute configurations of 1- 3 were determined by analysis of spectroscopic data, as well as by single-crystal X-ray analysis. Compound 1 has a previously unobserved 6/5/5 fused tricyclic ring system, in which the five-membered (middle) ring is, as revealed by X-ray analysis, perpendicular to a six-membered ring. Compound 2 possesses a hitherto unknown 5/6 fused spirobicyclic ring system. The cytotoxic activities of the isolated compounds 1- 6 were evaluated.
- Subjects
SESQUITERPENES; SPECTRUM analysis; X-ray research; ENDOPHYTIC fungi; SINGLE crystals
- Publication
European Journal of Organic Chemistry, 2014, Vol 2014, Issue 19, p3976
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201402262