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- Title
Highly Enantioselective Biginelli Reaction Catalyzed by Double Axially Chiral Bisphosphorylimides.
- Authors
An, Dong; Fan, Yan‐Sen; Gao, Yang; Zhu, Zi‐Qian; Zheng, Liang‐Yu; Zhang, Suo‐Qin
- Abstract
Double axially chiral bisphosphorylimides have been used as catalysts in enantioselective Biginelli reactions. The three-component reaction of aromatic aldehydes, thiourea, and ethyl acetoacetate took place by using 5 mol-% catalyst in ethyl acetate at 50 °C. A series of chiral dihydropyrimidinethiones (DHPMs) were obtained in high yields (up to 97 %) with good to high enantioselectivities (up to 96 % ee) in only 12 hours.
- Subjects
CATALYSIS; UREA; ORGANIC compounds; ALDEHYDES; ENANTIOSELECTIVE catalysis
- Publication
European Journal of Organic Chemistry, 2014, Vol 2014, Issue 2, p301
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201301560