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- Title
Total Synthesis of the Antifungal Natural Product Mollisin.
- Authors
Schwolow, Sonja; Kunz, Horst; Rheinheimer, Joachim; Opatz, Till
- Abstract
Mollisin, a bioactive polyketide secondary metabolite of the fungus Mollisia caesia, was synthesized in nine linear steps from commercially available 2,6-dimethyl-γ-pyrone. A key transformation in this first total synthesis of mollisin was the ipso substitution of an arylstannane, which permitted the otherwise cumbersome introduction of the characteristic dichloroacetyl moiety. The fungal fungicide was obtained in an overall yield of 9 %.
- Subjects
POLYKETIDES; FUNGICIDES; ACYLATION; CHEMICAL synthesis; NATURAL products
- Publication
European Journal of Organic Chemistry, 2013, Vol 2013, Issue 29, p6519
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201301088