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- Title
New insights into the pros and cons of cross-linking decellularized bioartificial organs.
- Authors
Kamal H. Hussein; Kyung-Mee Park; Yun-Suk Lee; Jae-Seok Woo; Byung-Jae Kang; Ki-Young Choi; Kyung-Sun Kang; Heung-Myong Woo; Hussein, Kamal H; Park, Kyung-Mee; Lee, Yun-Suk; Woo, Jae-Seok; Kang, Byung-Jae; Choi, Ki-Young; Kang, Kyung-Sun; Woo, Heung-Myong
- Abstract
Decellularization is an attractive method for scaffold designing in regenerative medicine. The resulting extracellular matrix (ECM) consists of structural proteins such as collagen and elastin, growth factors, and glycosaminoglycans, which can direct site-appropriate remodeling after in vivo implantation. Mainly, collagen and elastin of ECM are exposed to the enzymatic biodegradation in the host. To control the biodegradation process, treatment of decellularized tissue by a cross-linking agent is required. Cross-linking also reduces antigenicity and increases the storage properties. Cross-linkers should be nontoxic, with the ability to preserve the ECM components, especially glycosaminoglycans and associated growth factors for retention of scaffold bioactivity. In this review, we describe the different cross-linking agents and methods of evaluation of cross-linking efficiency.
- Publication
International Journal of Artificial Organs, 2017, Vol 40, Issue 4, p136
- ISSN
0391-3988
- Publication type
journal article
- DOI
10.5301/ijao.5000541