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- Title
Monitoring of First-line Drug Resistance Mutations Outside the Scope of Xpert MTB/RIF Ultra is Needed for Successful Control of DR-TB in Southern Mozambique.
- Authors
Mariner-Llicer, Carla; Cervera, Belén Saavedra; Mambuque, Edson; Gomes, Neide; Munguambe, Shilzia; Villamayor, Luis; Cancino-Muñoz, Irving; Torres-Puente, Manuela; Nguenha, Dinis; Respeito, Durval; Tembe, Gustavo; López, Mariana G; Comas, Iñaki; García-Basteiro, Alberto L
- Abstract
Multidrug-resistant(MDR) tuberculosis in Southern Africa is of great concern, exacerbated by the spread of a clone harboring a mutation missed by Xpert Ultra. In Southern Mozambique, the presence of such mutation and rising cases of non-MDR isoniazid resistance highlights the need to ensure accurate detection of antimicrobial-resistance in the country.
- Subjects
MOZAMBIQUE; GENOMICS; RESEARCH funding; MULTIDRUG resistance; DESCRIPTIVE statistics; ODDS ratio; GENETIC mutation; CONFIDENCE intervals; LATENT tuberculosis; MYCOBACTERIUM tuberculosis; MOLECULAR diagnosis; SEQUENCE analysis; SINGLE nucleotide polymorphisms; INFECTIOUS disease transmission
- Publication
Clinical Infectious Diseases, 2024, Vol 78, Issue 4, p842
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciad684