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- Title
Rapid Development of Cefiderocol Resistance in Carbapenem-resistant Enterobacter cloacae During Therapy Is Associated With Heterogeneous Mutations in the Catecholate Siderophore Receptor cirA.
- Authors
Klein, Sabrina; Boutin, Sébastien; Kocer, Kaan; Fiedler, Mascha O; Störzinger, Dominic; Weigand, Markus A; Tan, Benjamin; Richter, Daniel; Rupp, Christian; Mieth, Markus; Mehrabi, Arianeb; Hackert, Thilo; Zimmermann, Stefan; Heeg, Klaus; Nurjadi, Dennis
- Abstract
We report a case of resistance development toward cefiderocol in a patient with intra-abdominal and bloodstream infections caused by carbapenemase-producing Enterobacter cloacae within 21 days of cefiderocol therapy. Whole genome sequencing revealed heterogeneous mutations in the cirA gene, encoding a catecholate siderophore receptor, conferring phenotypic resistance to cefiderocol.
- Subjects
GENETIC mutation; SEQUENCE analysis; CARBAPENEM-resistant bacteria; CHELATING agents; CELL receptors; CEPHALOSPORINS; DRUG resistance in microorganisms; PHENOTYPES
- Publication
Clinical Infectious Diseases, 2022, Vol 74, Issue 5, p905
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciab511