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- Title
Atypical fibroxanthoma: a series of 25 cases.
- Authors
Wollina, U.; Schönlebe, J.; Koch, A.; Haroske, G.
- Abstract
Objective Atypical fibroxanthoma is a rare mesenchymal tumour of skin that develops on skin of elderly patients. We analysed our patients with atypical fibroxanthoma over the last 8 years. Patients and methods We analysed the pathology files of our hospital for the period 2001–2009. In all cases, histology and immunohistology were performed. Data on co-morbidities, treatment and outcome were obtained. Results We identified 25 patients (except two female patients, the rest were men) aged 52–95 years (mean: 79.5 years; standard deviation ± 9.06 years). All tumours were localized in the head and neck region, except a single tumour on the shoulder. Fourteen patients had a cancer history, six had actinic keratoses or Bowen’s disease ( n = 1). Five patients had cardiac surgery or pacemaker, one each had a renal transplant, systemic sarcoidosis or non-Hodgkin’s lymphoma. Medical history was positive for radiotherapy or chemotherapy in four patients. Histology showed a spindle-shaped dermal and subcutaneous tumour growth intermingled with multinucleated giant cells. The phenotype of tumour cells was vimentin-positive, but S100- and keratin-negative. Some tumours showed a focal expression of CD68. Complete microhistographic controlled surgery (‘Mohs like’) was possible in all cases followed by mesh-graft transplantation in three patients. Eighteen patients showed a complete remission. Four patients had a relapse within 2 years of follow-up treated by surgery. One patient is still under radiotherapy. All patients with a safety margin of 2 cm had no recurrence or relapse during follow-up. Conclusions Micrographic controlled surgery with wide 2 cm safety margins is the treatment of choice. A regular follow-up for the next 5 years is recommended.
- Subjects
CANCER genetics; SARCOMA; SKIN tumors; CARDIAC surgery patients; TUMOR growth; CANCER cell growth; CANCER risk factors
- Publication
Journal of the European Academy of Dermatology & Venereology, 2010, Vol 24, Issue 8, p943
- ISSN
0926-9959
- Publication type
Article
- DOI
10.1111/j.1468-3083.2010.03578.x