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- Title
OSTEOPOROZA ŞI ATEROSCLEROZA -- MECANISME OSTEOGENICE IMPLICATE ÎN PROCESUL DE CALCIFIERE VASCULARĂ.
- Authors
Simon, Siao-Pin; Rednic, Simona
- Abstract
Emerging epidemiologic evidence shows age-independent correlation between bone mineral density and cardiovascular events. Calcification is widely used as a clinical indicator of atherosclerosis. The relationship between calcification and clinical events likely relates to mechanical instability introduced by calcified plaque at its interface with softer, noncalcified plaque. Vascular calcification, long thought to result from passive degeneration, involves a complex, regulated process of biomineralization resembling osteogenesis. Evidence indicates that proteins controlling bone mineralization are also involved in the regulation of vascular calcification. Unravelling the mechanisms underlying the relationship between cardiovascular calcification and osteoporosis is an important step towards future therapeutic strategies -- therapies that enhance bone density and reduce atherogenesis hold futher promise to diminish the morbidity and mortality of osteoporosis and atherosclerosis.
- Subjects
OSTEOPOROSIS; ATHEROSCLEROSIS; BONE growth; CALCIFICATION; BONE density
- Publication
Romanian Journal of Rheumatology / Revista Romana de Reumatologie, 2011, Vol 20, Issue 3, p151
- ISSN
1843-0791
- Publication type
Article