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- Title
Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future.
- Authors
Kim, Y.-J.; Uyama, H.
- Abstract
Tyrosinase is known to be a key enzyme in melanin biosynthesis, involved in determining the color of mammalian skin and hair. Various dermatological disorders, such as melasma, age spots and sites of actinic damage, arise from the accumulation of an excessive level of epidermal pigmentation. In addition, unfavorable enzymatic browning of plant-derived foods by tyrosinase causes a decrease in nutritional quality and economic loss of food products. The inadequacy of current conventional techniques to prevent tyrosinase action encourages us to seek new potent tyrosinase inhibitors. This article overviews the various inhibitors obtained from natural and synthetic sources with their industrial importance.
- Subjects
PHENOL oxidase; BIOSYNTHESIS; EPIDERMIS; MELANOGENESIS; FOOD; FOOD color
- Publication
Cellular & Molecular Life Sciences, 2005, Vol 62, Issue 15, p1707
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-005-5054-y