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- Title
Osteoclast stimulatory transmembrane protein and dendritic cell-specific transmembrane protein cooperatively modulate cell-cell fusion to form osteoclasts and foreign body giant cells.
- Authors
Miyamoto, Hiroya; Suzuki, Takayuki; Miyauchi, Yoshiteru; Iwasaki, Ryotaro; Kobayashi, Tami; Sato, Yuiko; Miyamoto, Kana; Hoshi, Hiroko; Hashimoto, Kazuaki; Yoshida, Shigeyuki; Hao, Wu; Mori, Tomoaki; Kanagawa, Hiroya; Katsuyama, Eri; Fujie, Atsuhiro; Morioka, Hideo; Matsumoto, Morio; Chiba, Kazuhiro; Takeya, Motohiro; Toyama, Yoshiaki
- Abstract
Cell-cell fusion is a dynamic phenomenon promoting cytoskeletal reorganization and phenotypic changes. To characterize factors essential for fusion of macrophage lineage cells, we identified the multitransmembrane protein, osteoclast stimulatory transmembrane protein (OC-STAMP), and analyzed its function. OC-STAMP-deficient mice exhibited a complete lack of cell-cell fusion of osteoclasts and foreign body giant cells (FBGCs), both of which are macrophage-lineage multinuclear cells, although expression of dendritic cell specific transmembrane protein (DC-STAMP), which is also essential for osteoclast/FBGC fusion, was normal. Crossing OC-STAMP-overexpressing transgenic mice with OC-STAMP-deficient mice restored inhibited osteoclast and FBGC cell-cell fusion seen in OC-STAMP-deficient mice. Thus, fusogenic mechanisms in macrophage-lineage cells are regulated via OC-STAMP and DC-STAMP. © 2012 American Society for Bone and Mineral Research.
- Subjects
CELL fusion; OSTEOCLASTS; FOREIGN bodies; CYTOSKELETON; PROTEINS
- Publication
Journal of Bone & Mineral Research, 2012, Vol 27, Issue 6, p1289
- ISSN
0884-0431
- Publication type
Article
- DOI
10.1002/jbmr.1575