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- Title
Early Viral Clearance among COVID-19 Patients When Gargling with Povidone-Iodine and Essential Oils: A Clinical Trial.
- Authors
Mohamed, Nurul Azmawati; Baharom, Nizam; Sulaiman, Wan Shahida Wan; Rashid, Zetti Zainol; Wong Kon Ken; Ali, Umi Kalsom; Othman, Siti Norlia; Samat, Muttaqillah Najihan; Kori, Najma; Periyasamy, Petrick; Zakaria, Nor Azizan; Sugurmar, Agni Nhirmal Kumar; Kazmin, Nur Ezzaty Mohammad; Cheong Xiong Khee; Saniman, Siti Mariyam; Isahak, Ilina
- Abstract
Background: Gargling had been reported to have significant roles in the prevention and treatment of respiratory tract infections. The purpose of this study was to assess the ability of regular gargling to eliminate SARS-CoV-2 in the oropharynx and nasopharynx. Methodology: This pilot, open labeled, randomized, parallel study compared the effect of 30 seconds, 3 times/day gargling using 1% povidone-iodine (PVP-I), essential oils and tap water on SARS-CoV-2 viral clearance among COVID-19 patients in a tertiary hospital in Kuala Lumpur. Progress was monitored by day 4,6 and 12 PCR (Ct value), gargling and symptoms diary as well as clinical observations. Results: Five confirmed Stage 1 COVID-19 patients were recruited for each arm. The age range was from 22 to 56 years old. The majority were males. Two respondents had co-morbidities, which were asthma and obesity. Viral clearance was achieved at day 6 in 100%, 80%, 20% and 0% for 1% PVP-I, essential oils, tap water and control group respectively. Analysis of 1% PVP-I group versus control group showed significant p-value for comparison of PCR results on Day 4, Day 6 and Day 12. Conclusions: This preliminary study showed that gargling with 1% PVP-I and essential oils show great potential to be part of the treatment and management of Stage 1 COVID-19. Larger studies are required to ascertain the benefit of gargling for different stages of COVID-19 patients. This study was registered in clinicaltrial.gov (NCT04410159).
- Subjects
MALAYSIA; ASTHMA; ESSENTIAL oils; HOSPITALS; MOUTHWASHES; NASOPHARYNX; OBESITY; POLYMERASE chain reaction; POVIDONE-iodine; TOOTH care &; hygiene; WATER; DISEASE management; COMORBIDITY; PILOT projects; RANDOMIZED controlled trials; TREATMENT effectiveness; NASAL irrigation; DESCRIPTIVE statistics; OROPHARYNX; TERTIARY care; COVID-19
- Publication
International Medical Journal, 2020, Vol 27, Issue 6, p651
- ISSN
1341-2051
- Publication type
Article