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- Title
Methylation Regulates Alpha-Synuclein Expression and Is Decreased in Parkinson's Disease Patients' Brains.
- Authors
Jowaed, Ahmad; Schmitt, Ina; Kaut, Oliver; Wüllner, Ullrich
- Abstract
Alpha-synuclein (SNCA) is a major risk gene for Parkinson's disease (PD), and increased SNCA gene dosage results in a parkinsonian syndrome in affected families. We found that methylation of human SNCA intron 1 decreased gene expression, while inhibition of DNA methylation activated SNCA expression. Methylation of SNCA intron 1 was reduced in DNA from sporadic PD patients' substantia nigra, putamen, and cortex, pointing toward a yet unappreciated epigenetic regulation of SNCA expression in PD.
- Subjects
PARKINSON'S disease; BRAIN diseases; GENES; DISEASE risk factors; SUBSTANTIA nigra; GENE expression; DNA
- Publication
Journal of Neuroscience, 2010, Vol 30, Issue 18, p6355
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.6119-09.2010