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- Title
Persistence of Antibody and Cellular Immune Responses in COVID-19 patients over Nine Months after Infection.
- Authors
Yao, Lin; Wang, Guo-Lin; Shen, Yuan; Wang, Zhuang-Ye; Zhan, Bing-Dong; Duan, Li-Jun; Lu, Bing; Shi, Chao; Gao, Yu-Meng; Peng, Hong-Hong; Wang, Guo-Qiang; Wang, Dong-Mei; Jiang, Ming-Dong; Cao, Guo-Ping; Ma, Mai-Juan
- Abstract
<bold>Background: </bold>The duration of humoral and T and cell response after the infection of SARS-CoV-2 remains unclear.<bold>Methods: </bold>We performed a cross-sectional study to assess the virus-specific antibody and memory T and B cell responses in COVID-19 patients up to 343 days after infection. Neutralizing antibodies and antibodies against the receptor-binding domain, spike, and nucleoprotein of SARS-CoV-2 were measured. Virus-specific memory T and B cell responses were analyzed.<bold>Results: </bold>We enrolled 59 COVID-19 patients, including 38 moderate, 16 mild, and five asymptomatic patients; 31 (52.5%) were men, and 28 (47.5%) were women. The median age was 41 (interquartile range [IQR]: 30-55). The median day from symptom onset to enrollment was 317 days (range 257 to 343 days). We found that approximately 90% of patients still have detectable IgG antibodies against spike and nucleocapsid proteins and neutralizing antibodies against pseudovirus, whereas ~60% of patients had detectable IgG antibodies against receptor binding domain and surrogate virus-neutralizing antibodies. SARS-CoV-2-specific IgG + memory B cell and IFN-γ secreting T cell responses were detectable in over 70% of patients.<bold>Conclusions: </bold>SARS-CoV-2-specific immune memory response persists in most patients nearly one year after infection, which provides a promising sign for prevention from reinfection and vaccination strategy.
- Subjects
COVID-19; COVID-19 pandemic; HUMORAL immunity; IMMUNE response; IMMUNOLOGIC memory
- Publication
Journal of Infectious Diseases, 2021, Vol 224, Issue 4, p586
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiab255