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- Title
Identification of novel miRNA‐mRNA regulatory networks in contact dermatitis by integrated microarray analysis.
- Authors
Werner, Paulina; Wisgrill, Lukas; Riskumäki, Matilda; Jalonen, Erja; Vendelin, Johanna; Suomela, Sari; Lauerma, Antti; Alenius, Harri; Fyhrquist, Nanna
- Abstract
Keywords: allergic contact dermatitis; irritant contact dermatitis; miRNA; miRNA-mRNA integration EN allergic contact dermatitis irritant contact dermatitis miRNA miRNA-mRNA integration 1257 1261 5 04/14/21 20210401 NES 210401 Contact dermatitis (CD) is a major occupational disorder, characterized by pruritus and inflammation following direct topical exposure to an allergen or irritant.1 The role of micro RNAs (miRNAs) in skin diseases, including CD, has been investigated due to their compelling potential applicability.1 miRNAs are short single-stranded RNA molecules, which take part in the post-transcriptional regulation.1 Most previously conducted studies have focused on changes in miRNA expression profiles1-3; however, their regulatory effects as well as changes in the miRNAome in response to contact sensitizers and irritants with different physiochemical properties needs elucidation. Allergic contact dermatitis, irritant contact dermatitis, miRNA, miRNA-mRNA integration All differentially expressed miRNAs are listed in Figure S1 and highly relevant miRNAs are highlighted in Figure 1E. GLO:1X5/01apr21:all14578-fig-0001.jpg PHOTO (COLOR): 1 Allergic contact dermatitis and ICD induce different miRNA patterns.
- Subjects
CONTACT dermatitis; SODIUM dodecyl sulfate; GENE ontology; CD28 antigen
- Publication
Allergy, 2021, Vol 76, Issue 4, p1257
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.14578