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- Title
Trichoblastic Carcinosarcoma Arising From the Vagina: A Case Report With Comprehensive Immunophenotypic Analysis.
- Authors
Li, Joshua Jing Xi; Ng, Joanna Ka Man; Choi, Paul Cheung Lung; Lee, Jacqueline Ho Sze; Yu, Mei-yung
- Abstract
A 54-year-old woman presented with abdominal pain. Magnetic resonance imaging revealed an upper vaginal mass with no pelvic side wall involvement, nodal, or distant metastasis. Radical hysterectomy was performed. Histology showed trichoblastic carcinoma with hair follicle structures and malignant sarcomatous and carcinomatous components. Hair follicular differentiation was confirmed by positivity to hair follicle markers (Bcl-2, TLE1, CD56/NCAM, and TDAG51) and presence of CD10-positive trichogenic stroma. The tumor involved the vaginal muscularis only (FIGO [International Federation of Gynecology and Obstetrics] stage I) and was excised with clear margins. The patient remained disease free at 3-month follow-up. This is the first case of cutaneous-type carcinosarcoma reported in the vagina, highlighting the difference in histology, immunophenotype, and behavior compared with gynecologic carcinosarcomas.
- Subjects
VAGINA; MAGNETIC resonance imaging; CARCINOSARCOMAS; HAIR follicles; INTERNATIONAL organization; ABDOMINAL pain; FEMALE reproductive organs
- Publication
International Journal of Surgical Pathology, 2020, Vol 28, Issue 4, p440
- ISSN
1066-8969
- Publication type
Article
- DOI
10.1177/1066896919887803