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- Title
Isolation of (-)-Patchouli Alcohol from Patchouli Oil by Fractional Distillation and Crystallization.
- Authors
Zu Qing Su; Xiao Li Wu; Mei Jia Bao; Chu Wen Li; Song Zhi Kong; Zi Ren Su; Xiao Ping Lai; Yu Cui Li; Jian Nan Chen
- Abstract
Purpose: To establish a new and efficient method for the isolation of (-)-patchouli alcohol (PA) from patchouli oil (PO) . Methods: PO, obtained from commercial source, was separated into four fractions (A, B, C and raffinate) using fractional distillation according to pre-set reflux ratio in vacuum. PA was crystallized from fraction C (containing more than 80 % PA by weight) by cooling and centrifugation. Finally, PA was further purified by suction filtration. Characterization of PA was performed by melting point (MP), infrared spectroscopy (IR), ¹H and 13C nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS). Results: The total yield of PA in this procedure reached 52.9 %. The structure of PA was obtained based on data from ¹H-NMR, 13C-NMR and MS analysis with the aid of literature data for authenticated samples. Conclusion: Fractional distillation combined with crystallization can be successfully applied to the isolation of PA from PO in solvent-free conditions.
- Subjects
TERPENE alcohols; FRACTIONAL distillation; CRYSTALLIZATION; CENTRIFUGATION; INFRARED spectroscopy; NUCLEAR magnetic resonance spectroscopy; MELTING points; MASS spectrometry
- Publication
Tropical Journal of Pharmaceutical Research, 2014, Vol 13, Issue 3, p359
- ISSN
1596-5996
- Publication type
Article
- DOI
10.4314/tjpr.v13i3.7