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- Title
Musculoskeletal pitfalls in <sup>68</sup>Ga-PSMA PET/CT.
- Authors
de Macedo Pontes, Írline Cordeiro; Souza, Anthony Reis; Nunes Fonseca, Eduardo Kaiser Ururahy; Osawa, Akemi; Baroni, Ronaldo Hueb; Castro, Adham do Amaral e.
- Abstract
Prostate-specific membrane antigen (PSMA) is a transmembrane protein expressed in normal prostate cells and overexpressed in prostate cancer. Consequently, it is an important tool in the evaluation of prostate cancer, including the staging of high-risk patients and the assessment of biochemical recurrence. Despite the "specific" designation, benign musculoskeletal conditions, such as fractures, osteodegenerative changes, and fibrous dysplasia, can also show PSMA uptake, which can lead to misinterpretation of the imaging findings. Therefore, radiologists must be aware of these potential pitfalls, understand their causes, and fully analyze their morphologic features on unfused computed tomography (CT) and magnetic resonance imaging scans to correctly interpret the examination. In this pictorial essay, we review the basic characteristics of the 68Ga-PSMA positron-emission tomography/CT (PET/ CT) radiotracer, discuss potential causes of false-positive findings on 68Ga-PSMA PET/CT in the musculoskeletal system, and illustrate the corresponding imaging findings.
- Subjects
POSITRON emission tomography computed tomography; DYSPLASIA; PROSTATE-specific membrane antigen; MAGNETIC resonance imaging; DIAGNOSTIC imaging; PROSTATE; COMPUTED tomography; MEMBRANE proteins; ENDORECTAL ultrasonography; MUSCULOSKELETAL system
- Publication
Radiologia Brasileira, 2023, Vol 56, Issue 4, p220
- ISSN
0100-3984
- Publication type
Article
- DOI
10.1590/0100-3984.2023.0003