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- Title
20(S)-Protopanaxdiol Suppresses the Abnormal Granule-Monocyte Differentiation of Hematopoietic Stem Cells in 4T1 Breast Cancer-Bearing Mouse.
- Authors
Guo, Wen-Qin; Chen, Ying-Ge; Shi, Rong-Zhen; He, Kai; Wang, Jian-Feng; Shao, Jin-Hui; Wan, Jian-Bo; Gao, Jian-Li
- Abstract
Panax notoginseng (PN) has been used as a qi- and blood-activating (Huoxue) drug for thousands of years in China. It has also been widely used as an anticancer drug at present. As a Huoxue drug, the effect of PN on hematopoietic differentiation in tumor-bearing body has been paid more and more attention. Our research found that panax notoginseng saponins (PNS), especially panaxadiol saponins (PDS) and its aglucon 20(S)-Protopanaxdiol (PPD), could improve the immunosuppressive state by regulating the abnormal hematopoietic differentiation in a tumor-bearing body by multiple ways. An interesting phenomenon is that PDS reduced the neutrophil-lymphocyte ratio (NLR) via its inhibition effect on the granule-monocyte differentiation of spleen cells, which is associated with a decrease in the secretion of tumor MPO, G-CSF, PU.1, and C/EBPα. Otherwise, PDS increased the proportion of both hematopoietic stem cells and erythroid progenitor cells in the bone marrow, but inhibited spleen erythroid differentiation via inhibiting secretion of tumor EPO, GATA-1, and GATA-2. This study suggests that PNS regulated the tumor-induced abnormal granule-monocyte differentiation of hematopoietic stem cells, affecting the distribution and function of haemocytes in tumor-bearing mice.
- Subjects
ERYTHROCYTES; ANIMAL experimentation; ANTINEOPLASTIC agents; BONE marrow; BREAST tumors; CELL differentiation; GRANULOCYTE-colony stimulating factor; GINSENG; GLYCOSIDES; HEMATOPOIESIS; HEMATOPOIETIC stem cells; LYMPHOCYTES; MICE; MONOCYTES; NEUTROPHILS; PROTEINS; SPLEEN; CONNECTIVE tissue tumors; PHARMACODYNAMICS
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2020, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2020/8747023