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- Title
The gene encoding rat 3-phosphoglycerate dehydrogenase.
- Authors
Robbi, Mariette; Achouri, Younes; Szpirer, Claude; van Schaftingen, Emile
- Abstract
This article focuses on gene encoding. The first step of L-senne synthesis is catalyzed by 3-phosphoglycerate dehydrogenase (PHGDH), a ubiquitous enzyme in prokary- otes and eukaryotes. The sequence encoding this enzyme, now known for many species including rat and human, shows that it belongs to the family of D-hydroxyacid dehydrogenases which also compnses enzymes acting on D-glycerate and glycolate. Subcloning and sequencing showed that these clones contained intronless sequences with multiple mutations compared with the cDNA, allowing the conclusion that these sequences corresponded to pseudogenes.
- Subjects
PROTEINS; ENZYMOLOGY; BIOCHEMISTRY; BIOMOLECULES; ENOLASE; GENETIC mutation
- Publication
Mammalian Genome, 2000, Vol 11, Issue 11, p1034
- ISSN
0938-8990
- Publication type
Article
- DOI
10.1007/s003350010189