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- Title
Islet antibodies and remaining β-cell function 8 years after diagnosis of diabetes in young adults: a prospective follow-up of the nationwide Diabetes Incidence Study in Sweden.
- Authors
Schölin, A.; Björlund, L.; Borg, H.; Arnqvist, H.; Björk, E.; Blohmé, G.; Bolinder, J.; Eriksson, J. W.; Gudbjörnsdottir, S.; Nyström, L.; Östman, J.; Karlsson, A. F.; Sundkvist, G.
- Abstract
Schölin A, Björklund L, Borg H, Arnqvist H, Björk E, Blohmé G, Bolinder J, Eriksson JW, Gudbjörnsdottir S, Nyström L, Östman J, Karlsson AF, Sundkvist G (Uppsala University Hospital, Uppsala; Malmö University Hospital, Malmö; Linköping University Hospital, Linköping; South Stockholm General Hospital, Stockholm; Huddinge University Hospital, Huddinge; Umeå University Hospital, Umeå; Sahlgrenska University Hospital, Gothenburg; Umeå University, Umeå, Sweden). Islet antibodies and remaining β-cell function 8 years after diagnosis of diabetes in young adults: a prospective follow-up of the nationwide Diabetes Incidence Study in Sweden. J Intern Med 2004; 255: 384–391. To establish the prevalence of remaining β-cell function 8 years after diagnosis of diabetes in young adults and relate the findings to islet antibodies at diagnosis and 8 years later. Population-based cohort study. Nationwide from all Departments of Medicine and Endocrinology in Sweden. A total of 312 young (15–34 years old) adults diagnosed with diabetes during 1987–88. Plasma connecting peptide (C-peptide) 8 years after diagnosis. Preserved β-cell function was defined as measurable C-peptide levels. Three islet antibodies – cytoplasmic islet cell antibodies (ICA), glutamic acid decarboxylase antibodies and tyrosine phosphatase antibodies – were measured. Amongst 269 islet antibody positives (ab+) at diagnosis, preserved β-cell function was found in 16% (42/269) 8 years later and these patients had a higher body mass index (median 22.7 and 20.5 kg m−2, respectively; P = 0.0003), an increased frequency of one islet antibody (50 and 24%, respectively; P = 0.001), and a lower prevalence of ICA (55 and 6%, respectively; P = 0.007) at diagnosis compared with ab+ without remaining β-cell function. Amongst the 241 patients without detectable β-cell function at follow-up, 14 lacked islet antibodies, both at diagnosis and at follow-up. Sixteen per cent of patients with autoimmune type 1 diabetes had remaining β-cell function 8 years after diagnosis whereas 5.8% with β-cell failure lacked islet autoimmunity, both at diagnosis and at follow-up.
- Subjects
SWEDEN; PANCREATIC beta cells; CELL physiology; DIABETES; IMMUNOGLOBULINS; ISLANDS of Langerhans
- Publication
Journal of Internal Medicine, 2004, Vol 255, Issue 3, p384
- ISSN
0954-6820
- Publication type
Article
- DOI
10.1046/j.1365-2796.2003.01273.x