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- Title
Metaiodobenzylguanidine (MIBG) scintigraphy and computed tomography (CT) in clinical practice. Primary and secondary evaluation for localization of phaeochromocytomas.
- Authors
Berglund, A. Scott; Hulthen, U.L.; Manheim, P.; Thorsson, O.; Wollmer, P.; Tornquist, C.; Berglund, A S; Hulthén, U L; Manhem, P; Törnquist, C
- Abstract
<bold>Objective: </bold>To determine the diagnostic value of metaiodobenzylguanidine (MIBG) scintigraphy compared with computed tomography (CT) for the localization of phaeochromocytomas in clinical practice.<bold>Design: </bold>Retrospective comparison between MIBG scintigrams and CT for localization of phaeochromocytomas in all patients successively examined with MIBG scintigraphy in Malmö from 1984 until January 1997.<bold>Setting: </bold>Malmö University Hospital, Sweden.<bold>Subjects: </bold>Sixty-four patients with clinically suspected phaeochromocytomas.<bold>Main Outcome Measures: </bold>MIBG scintigrams and CTs classified as positive or negative based on original interpretations (primary evaluation) and in a secondary evaluation by one blinded examiner are assessed through histological confirmation or clinical rule out of phaeochromocytomas.<bold>Results: </bold>Twenty-five patients had surgically removed phaeochromocytomas. The remaining 39 patients had no proof of phaeochromocytomas. In the secondary evaluation, sensitivity for MIBG scintigraphy was 88% (22/25) and for CT was 100% (25/25). The specificity for MIBG scintigraphy was 89% (35/39) but only 50% for CT (18/36). Two out of a total of six extra-adrenal tumours were amongst the false-negative MIBG scintigrams.<bold>Conclusions: </bold>MIBG scintigraphy for the localization of phaeochromocytomas is superior to CT as far as specificity, whereas CT has a higher sensitivity. After biochemical diagnosis, CT will detect most phaeochromocytomas. MIBG scintigraphy can be of value in patients who show inconclusive results with biochemical testing and CT.
- Subjects
POSITRON emission tomography; MEDICAL screening
- Publication
Journal of Internal Medicine, 2001, Vol 249, Issue 3, p247
- ISSN
0954-6820
- Publication type
journal article
- DOI
10.1046/j.1365-2796.2001.00792.x