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- Title
Idiopathic oedema with increased cytokine production: a pathogenetic link?
- Authors
Hoffmann; Fontana; Steurer; Bollinger; Hoffmann, Ulrich; Hoffmann, U; Fontana, A; Steurer, J; Bollinger, A
- Abstract
We describe four patients with idiopathic oedema and elevated cytokines. All patients shared increased serum concentrations of soluble interleukin-2 receptors (sIL-2R). In three patients tumour necrosis factor alpha (TNF-alpha), gamma interferon (IFN-gamma) and interleukin-2 (IL-2) were transiently elevated. There was no evidence for an underlying disease. Based on experimental and clinical data it is hypothesized that oedema formation in our patients is the consequence of cytokine induced alteration of endothelial cells.
- Subjects
EDEMA; CYTOKINES; ENZYME-linked immunosorbent assay
- Publication
Journal of Internal Medicine, 1998, Vol 244, Issue 2, p179
- ISSN
0954-6820
- Publication type
journal article
- DOI
10.1046/j.1365-2796.1998.00326.x