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- Title
Does Aging Affect the Response of Vitamin E Status to Vitamin E Depletion and Supplementation?
- Authors
WINKLHOFER‐ROOB, BRIGITTE M.; ROOB, JOHANNES M.; MARITSCHNEGG, MICHAELA; SPRINZ, GRETE; HILLER, DORIS; MARKTFELDER, ELISABETH; PREINSBERGER, MELANIE; WUGA, SANDRA; SUNDL, ISABELLA; TIRAN, BEATE; CARDINAULT, NICOLAS; RIBALTA, JOSEP; ROCK, EDMOND
- Abstract
A vitamin E depletion/supplementation study was conducted in 100 healthy 20-75-year-old volunteers. The responses of vitamin E status to 3-week dietary vitamin E restriction to approximately 25% of recommended intake and 2-month unrestricted dietary intake plus 800 IU/d of RRR-α-tocopherol were studied as a function of age. Plasma α-tocopherol concentrations were closely related to cholesterol concentrations, which increased with age (P < 0.001). Upon dietary restriction, plasma α-tocopherol concentrations decreased significantly (P < 0.001) but independently of age. Plasma α-tocopherol responses to supplementation increased significantly with age, but this effect disappeared after standardization for cholesterol. γ-Tocopherol concentrations decreased to less than 30% of baseline.
- Subjects
AGING; VITAMIN E; CHOLESTEROL; ISOPENTENOIDS; STEROLS
- Publication
Annals of the New York Academy of Sciences, 2004, Vol 1031, Issue 1, p381
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1331.050