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- Title
Clinical and Angiographic Outcomes with Everolimus Eluting Stents for the Treatment of Cardiac Allograft Vasculopathy.
- Authors
AZARBAL, BABAK; ARBIT, BORIS; RAMARAJ, RADHAKRISHNAN; KITTLESON, MICHELLE; YOUNG, AMELIA; CZER, LAWRENCE; RAFIEI, MATTHEW; CURRIER, JESSE; MAKKAR, RAJ; KOBASHIGAWA, JON
- Abstract
Objectives This study aimed to examine clinical efficacy, safety, and intermediate clinical outcomes with everolimus-eluting stents (EESs) in patients with transplant coronary artery disease (TCAD). Background TCAD is a major cause of mortality in patients following orthotopic heart transplantation (OHT). Systemic everolimus in OHT patients has been shown to reduce TCAD. The safety and efficacy of an EES, the Xience V, have not been evaluated in this population. Methods Patients post-OHT with hemodynamically significant CAD who underwent percutaneous coronary intervention (PCI) with EES were included. Participants were maintained on dual antiplatelet therapy for 1-year post-PCI. We examined procedural success, in-hospital and 1-year mortality, stent thrombosis, angiographic restenosis, and myocardial infarction rates. All patients had follow-up angiography 1-year after PCI. Target vessel revascularization (TVR), target lesion revascularization (TLR), in-segment restenosis, target vessel failure (TVF), and lumen late loss were noted. Results PCI was performed in 34 de novo lesions in 21 patients, and 40 EES were placed. Procedural success rate was 100%. Average stent was 16.5 ± 5.1 mm long and 3.0 ± 0.6 mm in diameter. All patients had angiographic follow-up (409 ± 201 days). There was no stent thrombosis, deaths, or myocardial infarctions during follow-up. Two patients had focal in-stent restenosis. TLR rate was 5.9% (2/34), and TVR rate was 11.1% (3/27). Quantitative coronary angiography (QCA) showed stenosis diameter to be 19.98 ± 17.57%. Conclusions Use of an EES is associated with a low incidence of TVR and TLR in patients with TCAD. Further studies are needed to determine whether PCI with EES changes long-term outcomes. (J Interven Cardiol 2014;27:73-79)
- Subjects
CORONARY angiography; HEALTH outcome assessment; EVEROLIMUS; CORONARY disease; DRUG-eluting stents; CORONARY heart disease treatment; CLINICAL trials; PATIENTS
- Publication
Journal of Interventional Cardiology, 2014, Vol 27, Issue 1, p73
- ISSN
0896-4327
- Publication type
Article
- DOI
10.1111/joic.12071