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- Title
Access to 1,2-Dihydroisoquinolines through Gold-Catalyzed Formal [4+2] Cycloaddition.
- Authors
Xin, Zhuo; Kramer, Søren; Overgaard, Jacob; Skrydstrup, Troels
- Abstract
A new synthetic route to the privileged 1,2-dihydroisoquinolines is reported. This method, which relies on a gold-catalyzed formal [4+2] cycloaddition between ynamides and imines, provides a new retrosynthetic disconnection of the 1,2-dihydroisoquinoline core by installing the 1,8a CC and 2,3 CN bonds in one step. Both aldimines and ketimines can be used as substrates. In addition, one example of dihydrofuropyridine synthesis is also demonstrated.
- Subjects
ISOQUINOLINE; RING formation (Chemistry); YNAMIDES; ALDIMINES; IMINES; CHEMICAL synthesis
- Publication
Chemistry - A European Journal, 2014, Vol 20, Issue 26, p7926
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201403290