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- Title
Direct α-Siladifluoromethylation of Lithium Enolates with Ruppert-Prakash Reagent via CF Bond Activation.
- Authors
Hashimoto, Ryota; Iida, Toshiaki; Aikawa, Kohsuke; Ito, Shigekazu; Mikami, Koichi
- Abstract
The direct α-siladifluoromethylation of lithium enolates with the Ruppert-Prakash reagent (CF3TMS) is shown to construct the tertiary and quaternary carbon centers. The Ruppert-Prakash reagent, which is versatile for various trifluoromethylation as a trifluoromethyl anion (CF3−) equivalent, can be employed as a siladifluoromethyl cation (TMSCF2+) equivalent by CF bond activation due to the strong interaction between lithium and fluorine atoms.
- Subjects
LITHIUM enolates; CHEMICAL reagents; FLUORINE compounds; ANIONS; CHEMICAL bonds
- Publication
Chemistry - A European Journal, 2014, Vol 20, Issue 10, p2750
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201304473