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- Title
Highly Enantioselective Iridium-Catalyzed Hydrogenation of α,β-Unsaturated Esters.
- Authors
Li, Jia-Qi; Quan, Xu; Andersson, Pher G.
- Abstract
α,β-Unsaturated esters have been employed as substrates in iridium-catalyzed asymmetric hydrogenation. Full conversions and good to excellent enantioselectivities (up to 99 % ee) were obtained for a broad range of substrates with both aromatic- and aliphatic substituents on the prochiral carbon. The hydrogenated products are highly useful as building blocks in the synthesis of a variety of natural products and pharmaceuticals.
- Publication
Chemistry - A European Journal, 2012, Vol 18, Issue 34, p10609
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201200907