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- Title
Effective collection of peripheral blood stem cells in children weighing 20 kilogram or less in a single large-volume apheresis procedure.
- Authors
Salazar‐Riojas, Rosario; García‐Lozano, José Alberto; Valdés‐Galván, Mayra; Martínez‐González, Odra; Cantú‐Rodríguez, Olga Graciela; González‐Llano, Oscar; Gómez‐De León, Andrés; Jaime‐Pérez, José Carlos; Gómez‐Almaguer, David; Gutiérrez‐Aguirre, César Homero
- Abstract
Introduction: Peripheral blood stem cell (PBSC) transplantation has become a routine procedure in pediatric oncology. A special group of PBSC donors are children weighing 20 kg or less. Limited vascular access and low blood volume puts them at a higher risk. Central line placement and a priming apheresis machine are recommended to avoid these complications. Patients and Methods: PBSC collections performed from July 2006 to May 2013 in children weighing less than 20 kg were included. All donors had a central venous catheter (CVC). An apheresis machine was primed with packet red blood cells. Results: Twenty-seven PBSC collections were performed in 22 children weighing 20 kg or less, 14 for allogeneic and 8 for autologous transplantation, in order to collect at least 2 × 106 CD34+ cells/kg. In the allogeneic group, median age and weight were 3 years (0.8-7) and 15.5 kg (8-20). In the autologous group, median age and weight were 3 years (2-7) and 15.35 kg (12.5-19.5). A single large-volume apheresis was sufficient to obtain the CD34+ cells needed in 78.5% and 75% of the allogeneic and autologous groups, respectively, with a median 11.84 × 106 and 5.79 × 106 CD34+ cells collected per kilogram of weight of the recipient. No serious complications related to the apheresis procedure or CVC placement occurred. Conclusion: PBSC collection in a single large-volume apheresis for allogeneic and autologous transplants in children weighing 20 kg or less is a safe and effective procedure when based on standardized protocols. J. Clin. Apheresis 30:281-287, 2015. © 2014 Wiley Periodicals, Inc.
- Publication
Journal of Clinical Apheresis, 2015, Vol 30, Issue 5, p281
- ISSN
0733-2459
- Publication type
Article
- DOI
10.1002/jca.21375