We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Mapping Structural Connectivity Using Diffusion MRI: Challenges and Opportunities.
- Authors
Yeh, Chun‐Hung; Jones, Derek K.; Liang, Xiaoyun; Descoteaux, Maxime; Connelly, Alan; Yeh, Chun-Hung
- Abstract
Diffusion MRI-based tractography is the most commonly-used technique when inferring the structural brain connectome, i.e., the comprehensive map of the connections in the brain. The utility of graph theory-a powerful mathematical approach for modeling complex network systems-for analyzing tractography-based connectomes brings important opportunities to interrogate connectome data, providing novel insights into the connectivity patterns and topological characteristics of brain structural networks. When applying this framework, however, there are challenges, particularly regarding methodological and biological plausibility. This article describes the challenges surrounding quantitative tractography and potential solutions. In addition, challenges related to the calculation of global network metrics based on graph theory are discussed.Evidence Level: 5Technical Efficacy: Stage 1.
- Subjects
DIFFUSION magnetic resonance imaging; UTILITY theory; GRAPH theory; BRAIN mapping; MATHEMATICAL models
- Publication
Journal of Magnetic Resonance Imaging, 2021, Vol 53, Issue 6, p1666
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.27188