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- Title
Practical Approaches to Bone Marrow Fat Fraction Quantification Across Magnetic Resonance Imaging Platforms.
- Authors
Bainbridge, Alan; Bray, Timothy J.P.; Sengupta, Raj; Hall‐Craggs, Margaret A.; Hall-Craggs, Margaret A
- Abstract
<bold>Background: </bold>Quantification of fat by proton density fat fraction (PDFF) measurements may be valuable for the quantification and follow-up of pathology in multicenter clinical trials and routine practice. However, many centers do not have access to specialist methods (such as chemical shift imaging) for PDFF measurement. This is a barrier to more widespread trial implementation.<bold>Purpose/hypothesis: </bold>To determine the agreement between fat fraction (FF) measurements derived from 1) basic vendor-supplied sequences, 2) basic sequences with offline correction, and 3) specialist vendor-supplied methods.<bold>Study Type: </bold>Prospective.<bold>Population: </bold>Two substudies with ten and five healthy volunteers.<bold>Field Strength/sequence: </bold>Site A: mDixon Quant (Philips 3T Ingenia); Site B: IDEAL and FLEX (GE 1.5T Optima MR450W); Site C: DIXON, with additional 5-echo gradient echo acquisition for offline correction (Siemens 3T Skyra); Site D: DIXON, with additional VIBE acquisitions for offline correction (Siemens 1.5T Avanto). The specialist method at site A was used as a standard to compare to the basic methods at sites B, C, and D.<bold>Assessment: </bold>Regions of interest were placed on areas of subchondral bone on FF maps from the various methods in each volunteer.<bold>Statistical Tests: </bold>Relationships between FF measurements from the various sites and Dixon methods were assessed using Bland-Altman analysis and linear regression.<bold>Results: </bold>Basic methods consisting of IDEAL, LAVA FLEX, and DIXON produced FF values that were linearly related to reference FF values (P < 0.0001), but produced mean biases of up to 10%. Offline correction produced a significant reduction in bias in both substudies (P < 0.001).<bold>Data Conclusion: </bold>FF measurements derived using basic vendor-supplied methods are strongly linearly related with those derived using specialist methods but produce a bias of up to 10%. A simple offline correction that is accessible even when the scanner has only basic sequence options can significantly reduce bias.<bold>Level Of Evidence: </bold>2 Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2020;52:298-306.
- Subjects
MAGNETIC resonance imaging; BONE marrow; CLINICAL pathology; REGRESSION analysis; BONES; RESEARCH; RESEARCH evaluation; RESEARCH methodology; MEDICAL cooperation; EVALUATION research; COMPARATIVE studies; RESEARCH funding; ADIPOSE tissues; LONGITUDINAL method
- Publication
Journal of Magnetic Resonance Imaging, 2020, Vol 52, Issue 1, p298
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.27039