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- Title
Intrinsic brain network abnormalities in codeine-containing cough syrup-dependent male individuals revealed in resting-state fMRI.
- Authors
Qiu, Ying‐wei; Su, Huan‐Huan; Lv, Xiao‐fei; Ma, Xiao‐fen; Jiang, Gui‐hua; Tian, Jun‐zhang; Qiu, Ying-Wei; Su, Huan-Huan; Lv, Xiao-Fei; Ma, Xiao-Fen; Jiang, Gui-Hua; Tian, Jun-Zhang
- Abstract
<bold>Purpose: </bold>To identify codeine-containing cough syrups (CCS)-related modulations of intrinsic connectivity network (ICN) and to investigate whether these changes of ICN can be related to duration of CCS use and to impulsivity behavior in CCS-dependent individuals.<bold>Materials and Methods: </bold>Resting-state functional magnetic resonance imaging (fMRI) data in 41 CCS-dependent individuals and 34 healthy controls (HC) were scanned at 1.5T and analyzed using independent component analysis (ICA), in combination with a "dual-regression" technique to identify the group differences of three important resting-state networks, the default mode network (DMN), the executive control network (ECN), and the salience network (SN) between the CCS-dependent individuals and HC.<bold>Results: </bold>Compared with the HC, CCS-dependent individuals had aberrant intrinsic connectivity within the DMN, ECN, and SN (P < 0.05, AlphaSim corrected). Furthermore, a longer duration of CCS use was associated with greater abnormalities in the intrinsic network functional connectivity (FC, P < 0.05, Bonferroni correction). Intrinsic network FC also correlated with higher impulsivity in CCS-dependent individuals (P < 0.05, AlphaSim corrected).<bold>Conclusion: </bold>Our findings revealed aberrant DMN, ECN, and SN connectivity patterns in CCS-dependent patients, which may provide new insight into how neuronal communication and information integration are disrupted among DMN, ECN, and SN key structures due to long duration of CCS use.<bold>Level Of Evidence: </bold>1 J. Magn. Reson. Imaging 2017;45:177-186.
- Subjects
ANTITUSSIVE agents; BRAIN; BRAIN mapping; CODEINE; COMPARATIVE studies; MAGNETIC resonance imaging; RESEARCH methodology; MEDICAL cooperation; NERVOUS system; RELAXATION for health; RESEARCH; RESEARCH evaluation; EVALUATION research; RANDOMIZED controlled trials; NEURAL pathways
- Publication
Journal of Magnetic Resonance Imaging, 2017, Vol 45, Issue 1, p177
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.25352