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- Title
Multiple sclerosis during adalimumab treatment in a case with ankylosing spondylitis.
- Authors
Uygunoğlu, Uğur; Uluduz, Derya; Taşçılar, Koray; Saip, Sabahattin
- Abstract
Ankylosing spondylitis is a chronic and progressive inflammatory disease involving the sacroiliac joints with HLA-B27 positivity in 85 % of the patients and radiologically evidence of sacroiliitis. It is associated with several extraarticular manifestations, but neurological complications are rare. Occurrence of multiple sclerosis in patients with ankylosing spondylitis has been reported in limited cases. Adalimumab, a TNF-α antagonist, offers a significant improvement in ankylosing spondylitis and is considered to be less immunogenic and more tolerable than other TNF-α blockers. A case of multiple sclerosis coexisted with HLA-B27 positive ankylosing spondylitis after treated with adalimumab was reported.
- Subjects
ANKYLOSING spondylitis treatment; ADALIMUMAB; MULTIPLE sclerosis; DRUG side effects; INFLAMMATION; SACROILIAC joint diseases; HLA histocompatibility antigens
- Publication
Rheumatology International, 2014, Vol 34, Issue 1, p141
- ISSN
0172-8172
- Publication type
Article
- DOI
10.1007/s00296-012-2625-8