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- Title
The importance of alpha-fodrin antibodies in the diagnosis of Sjögren’s syndrome.
- Authors
Turkçapar, Nuran; Olmez, Umit; Tutkak, Huseyin; Duman, Murat
- Abstract
Objective: We wanted to determine the prevalence of IgA and IgG antibodies against alpha-fodrin in the patients with primary and secondary Sjögren’s syndrome (SS) and also to compare with anti-Ro and anti-La antibodies in the diagnosis of SS. Methods: We tested the prevalence of anti-alpha-fodrin IgA, IgG, anti-Ro, anti-La antibodies, anti-nuclear antibodies (ANA) and rheumatoid factor (RF) in naive patients with primary ( n=20) and secondary SS ( n=20) (Rheumatoid Arthritis [RA]+SS, n=10; Systemic Lupus Erythematosus [SLE]+SS, n=10), RA ( n=10), SLE ( n=10) and in healthy controls ( n=20). Salivary gland biopsies were performed in the patients with primary and secondary SS. Results: In primary SS, anti-alpha-fodrin IgA, IgG, anti-Ro and anti-La antibodies were detected as 20, 10, 55 and 20% respectively. In RA+SS, anti-alpha-fodrin IgA was detected to be 10% and IgG was negative; however, anti-Ro antibodies and anti-La antibodies were found to be 40% and 20% respectively. In SLE+SS, anti-alpha-fodrin IgA was found to be 20% and IgG was found to be 10%, but anti-Ro and anti-La antibodies were found to be 90% and 20% respectively. Alpha-fodrin antibodies were not detected in RA, SLE and healthy controls. Conclusion: The detection of anti-alpha-fodrin antibodies by used ELISA does not give much contribution to the diagnosis of SS, and anti-Ro and anti-La are still useful serological markers in the diagnosis of SS.
- Subjects
IMMUNOGLOBULIN A; IMMUNOGLOBULINS; SJOGREN'S syndrome; KERATOCONJUNCTIVITIS sicca; AUTOANTIBODIES; SYSTEMIC lupus erythematosus; VASCULAR diseases; RHEUMATOID arthritis
- Publication
Rheumatology International, 2006, Vol 26, Issue 4, p354
- ISSN
0172-8172
- Publication type
Article
- DOI
10.1007/s00296-005-0607-9