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- Title
Synthesis of Multifunctional Eu(III) Complex Doped Fe 3 O 4 /Au Nanocomposite for Dual Photo-Magnetic Hyperthermia and Fluorescence Bioimaging.
- Authors
Khuyen, Hoang Thi; Huong, Tran Thu; Van, Nguyen Duc; Huong, Nguyen Thanh; Vu, Nguyen; Lien, Pham Thi; Nam, Pham Hong; Nghia, Vu Xuan
- Abstract
In this paper, the luminescent complex Eu(3-thenoyltrifluoroacetonate)3 was integrated with Fe3O4 and gold (Au) nanoparticles to form a multifunctional nanocomposite, Fe3O4/Au/Eu(TTA)3 (FOASET NC), for dual magnetic-photothermal therapy and biomedical imaging. Upon functionalization with amine-NH2, the FOASET NC exhibits a small size of 60–70 nm and strong, sharp emission at λmax = 614 nm, enhanced by surface plasmon resonance (SPR) of Au nanoparticles that provided an effective label for HT29 colorectal cancer cells by fluorescence microscopy imaging. In addition, a hyperthermia temperature (42–46 °C) was completely achieved by using these FOASET NCs in an aqueous solution with three heating modes for (i) Magnetic therapy (MT), (ii) Photothermal therapy (PT), and (iii) Dual magnetic-photothermal therapy (MPT). The heating efficiency was improved in the dual magnetic-photothermal heating mode.
- Subjects
IRON oxides; FEVER; SURFACE plasmon resonance; NANOCOMPOSITE materials; GOLD nanoparticles
- Publication
Molecules, 2023, Vol 28, Issue 2, p749
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28020749