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- Title
Diversified Chaetoglobosins from the Marine-Derived Fungus Emericellopsis sp. SCSIO41202.
- Authors
Shao, Surun; Wang, Xueni; She, Jianglian; Zhang, Han; Pang, Xiaoyan; Lin, Xiuping; Zhou, Xuefeng; Liu, Yonghong; Li, Yunqiu; Yang, Bin
- Abstract
Two undescribed cytochalasins, emeriglobosins A (1) and B (2), together with nine previously reported analogues (3–11) and two known tetramic acid derivatives (12, 13) were isolated from the solid culture of Emericellopsis sp. SCSIO41202. Their structures, including the absolute configurations of their stereogenic carbons, were fully elucidated based on spectroscopic analysis and the calculated ECD. Some of the isolated compounds were evaluated for their cytotoxicity and enzyme inhibitory activity against acetylcholinesterase (AChE) in vitro. Among them, 8 showed potent AChE inhibitory activity, with an IC50 value of 1.31 μM, and 5 showed significant cytotoxicity against PC-3 cells, with an IC50 value of 2.32 μM.
- Subjects
ACETYLCHOLINESTERASE; TETRAMIC acids; ACID derivatives; CYTOCHALASINS; DIKETOPIPERAZINES; FUNGI
- Publication
Molecules, 2022, Vol 27, Issue 6, p1823
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules27061823