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- Title
Krill Oil Attenuates Cognitive Impairment by the Regulation of Oxidative Stress and Neuronal Apoptosis in an Amyloid β-Induced Alzheimer's Disease Mouse Model.
- Authors
Kim, Ji Hyun; Meng, Hui Wen; He, Mei Tong; Choi, Ji Myung; Lee, Dongjun; Cho, Eun Ju
- Abstract
In the present study, we investigated the cognitive improvement effects and its mechanisms of krill oil (KO) in Aβ25–35-induced Alzheimer's disease (AD) mouse model. The Aβ25–35-injected AD mouse showed memory and cognitive impairment in the behavior tests. However, the administration of KO improved novel object recognition ability and passive avoidance ability compared with Aβ25–35-injected control mice in behavior tests. In addition, KO-administered mice showed shorter latency to find the hidden platform in a Morris water maze test, indicating that KO improved learning and memory abilities. To evaluate the cognitive improvement mechanisms of KO, we measured the oxidative stress-related biomarkers and apoptosis-related protein expressions in the brain. The administration of KO inhibited oxidative stress-related biomarkers such as reactive oxygen species, malondialdehyde, and nitric oxide compared with AD control mice induced by Aβ25–35. In addition, KO-administered mice showed down-regulation of Bax/Bcl-2 ratio in the brain. Therefore, this study indicated that KO-administered mice improved cognitive function against Aβ25–35 by attenuations of neuronal oxidative stress and neuronal apoptosis. It suggests that KO might be a potential agent for prevention and treatment of AD.
- Subjects
COGNITION disorders; ALZHEIMER'S disease; REACTIVE oxygen species; OXIDATIVE stress; MOUSE diseases; AMYLOID plaque
- Publication
Molecules, 2020, Vol 25, Issue 17, p3942
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25173942