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- Title
Suppressive Effects of EGCG on Cervical Cancer.
- Authors
Ying-Qi Wang; Jian-Liang Lu; Yue-Rong Liang; Qing-Sheng Li
- Abstract
Cervical cancer is the fourth most common gynecological cancer worldwide. Although prophylactic vaccination presents the most effective method for cervical cancer prevention, chemotherapy is still the primary invasive intervention. It is urgent to exploit low-toxic natural anticancer drugs on account of high cytotoxicity and side-effects of conventional agents. As a natural product, (-)-epigallocatechingallate (EGCG) has abilities in anti-proliferation, anti-metastasis and pro-apoptosis of cervical cancer cells. Moreover, EGCG also has pharmaceutical synergistic effects with conventional agents such as cisplatin (CDDP) and bleomycin (BLM). The underlying mechanisms of EGCG suppressive effects on cervical cancer are reviewed in this article. Further research directions and ambiguous results are also discussed.
- Subjects
CERVICAL cancer; EPIGALLOCATECHIN gallate; BLEOMYCIN; ANTINEOPLASTIC antibiotics; CISPLATIN
- Publication
Molecules, 2018, Vol 23, Issue 9, p2334
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules23092334