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- Title
A New Nortriterpenoid, a Sesquiterpene and Hepatoprotective Lignans Isolated from the Fruit of Schisandra chinensis.
- Authors
Fenghua Li; Ting Zhang; Hua Sun; Haifeng Gu; Hongqing Wang; Xianming Su; Changkang Li; Baoming Li; Ruoyun Chen; Jie Kang
- Abstract
A new nortriterpenoid, 19(R)-hydroxyl-wuweizidilactone H (1), and a sesquiterpene, (6R)-β-chamigrenic acid (2), together with one known nortriterpenoid, wuweizidilactone H (3), and three known hepatoprotective lignans, micrantherin A (4), gomisin M2 (5) and schizandrin (6) were isolated from the fruit of Schisandra chinensis. Their structures were elucidated by UV, IR, HRESIMS, NMR spectra and X-ray analysis. Among them, the absolute configuration of 2 was confirmed for the first time. In vitro assays, compounds 4-6 (10 µM) exhibited hepatoprotective activities (survival rate: 44%, 43% and 44%) against damage induced by N-acetyl-p-aminophenol (APAP) in human liver carcinoma (HepG2) cells.
- Subjects
SESQUITERPENES; TERPENES; LIGNANS; SCHISANDRA; AMINOPHENOLS
- Publication
Molecules, 2017, Vol 22, Issue 11, p1931
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules22111931